Increasing efficiency for estimating treatment–biomarker interactions with historical data
نویسندگان
چکیده
منابع مشابه
Increasing efficiency for estimating treatment-biomarker interactions with historical data.
Detecting a treatment-biomarker interaction, which is a task better suited for large sample sizes, in a phase II trial, which has a small sample size, is challenging. In this paper, we investigate how two plausibly available sources of historical data may contain partial information to help estimate the treatment-biomarker interaction parameter in a randomized phase II study. The parameter is n...
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ژورنال
عنوان ژورنال: Statistical Methods in Medical Research
سال: 2016
ISSN: 0962-2802,1477-0334
DOI: 10.1177/0962280214535370